Sources/Clones
Accurate (2C2G7, 85D4), Axcel/Accurate (polyclonal), American Qualex (polyclonal), Biodesign (PA), Biogenesis (2D1-2, polyclonal), Biogenex (2D1-2, polyclonal), Calbiochem (polyclonal), Caltag Laboratories, Chemicon, Coulter (D1G10VL2, E3F8E5), Dako (polyclonal), EY Labs, Immunotech (D1G10VL2, E3F8E5), Seralab (polyclonal) and Sigma (85D4, FG21).
Fixation/Preparation
Fibrinogen is fixative resistant.
Background
Fibrinogen is a 340 kD multisubunit glycoprotein present in plasma and tissue of all classes of vertebrates. It has a variety of physiologically important functions, most of which, if not all, are assigned to certain structures of fibrin including double-stranded fibrin protofibrils and highly crosslinked fibrin networks (Shafer & Higgins, 1988; Mosessan 1997). Its role in hemostasis and thrombosis has been extensively studied (Henschen, 1983; Mosessan, 1992; Blomback, 1996; Gaffney, 1997).
Applications
Diagnostic applications of fibrinogen are largely limited to the identification of fibrinogen deposition and breakdown products in glomerular diseases (Dowling 1993).
Comments
None.
References
•Blomback B 1996. Fibrinogen and fibrin proteins with complex roles in hemostasis and thrombosis. Thrombosis Research 83: 1-75.
•Dowling JP 1993. Immunohistochemistry of renal diseases and tumours. In: Leong AS-Y (ed). Applied immunohistochemistry for surgical pathologists. London: Edward Arnold, pp 210-259.
•Gaffney PJ 1997. Structure of fibrinogen and degradation products of fibrinogen and fibrin. British Medical Bulletin 33: 245-251.
•Henschen A 1983. On the structure of functional sites in fibrinogen. Thrombosis Research 5 (Suppl.): 27-39.
•Mosessan MW 1992. The roles of fibrinogen and fibrin in hemostasis and thrombosis. Seminars in Hematology 29: 177-188.
•Mosessan MW 1997. Fibrinogen and fibrin polymerization: appraisal of the binding events that accompany fibrin generation and fibrin clot assembly. Blood Coagulation and Fibrinolysis 8: 257-267.
•Shafer JA, Higgins DL 1988. Human fibrinogen. Critical Reviews in Clinical Laboratory Science 26: 1-41.
Bibliografía
Manual of diagnostic antibodies for immunohistology / Anthony S.-Y. Leong, Kumarasen Cooper, F. Joel W.-M. Leong.
Accurate (2C2G7, 85D4), Axcel/Accurate (polyclonal), American Qualex (polyclonal), Biodesign (PA), Biogenesis (2D1-2, polyclonal), Biogenex (2D1-2, polyclonal), Calbiochem (polyclonal), Caltag Laboratories, Chemicon, Coulter (D1G10VL2, E3F8E5), Dako (polyclonal), EY Labs, Immunotech (D1G10VL2, E3F8E5), Seralab (polyclonal) and Sigma (85D4, FG21).
Fixation/Preparation
Fibrinogen is fixative resistant.
Background
Fibrinogen is a 340 kD multisubunit glycoprotein present in plasma and tissue of all classes of vertebrates. It has a variety of physiologically important functions, most of which, if not all, are assigned to certain structures of fibrin including double-stranded fibrin protofibrils and highly crosslinked fibrin networks (Shafer & Higgins, 1988; Mosessan 1997). Its role in hemostasis and thrombosis has been extensively studied (Henschen, 1983; Mosessan, 1992; Blomback, 1996; Gaffney, 1997).
Applications
Diagnostic applications of fibrinogen are largely limited to the identification of fibrinogen deposition and breakdown products in glomerular diseases (Dowling 1993).
Comments
None.
References
•Blomback B 1996. Fibrinogen and fibrin proteins with complex roles in hemostasis and thrombosis. Thrombosis Research 83: 1-75.
•Dowling JP 1993. Immunohistochemistry of renal diseases and tumours. In: Leong AS-Y (ed). Applied immunohistochemistry for surgical pathologists. London: Edward Arnold, pp 210-259.
•Gaffney PJ 1997. Structure of fibrinogen and degradation products of fibrinogen and fibrin. British Medical Bulletin 33: 245-251.
•Henschen A 1983. On the structure of functional sites in fibrinogen. Thrombosis Research 5 (Suppl.): 27-39.
•Mosessan MW 1992. The roles of fibrinogen and fibrin in hemostasis and thrombosis. Seminars in Hematology 29: 177-188.
•Mosessan MW 1997. Fibrinogen and fibrin polymerization: appraisal of the binding events that accompany fibrin generation and fibrin clot assembly. Blood Coagulation and Fibrinolysis 8: 257-267.
•Shafer JA, Higgins DL 1988. Human fibrinogen. Critical Reviews in Clinical Laboratory Science 26: 1-41.
Bibliografía
Manual of diagnostic antibodies for immunohistology / Anthony S.-Y. Leong, Kumarasen Cooper, F. Joel W.-M. Leong.
